what is lisinopril?

About Lisinopril pills in different forms
Drug class
Antihypertensive
ACE inhibitors
Finished products (selection)
Zestril ®
Lisibeta ®
LisiHEXAL ®
Effect
Lisinopril inhibits angiotensin-converting enzyme, angiotensin I into
angiotensin II leads. The formation of angiotensin II, one of the
strongest blood pressure-enhancing drugs is suppressed, and as a
consequence of reduced peripheral resistance. Lisinopril is in
hypertension, heart failure, hypertension, used with incipient
diabetic nephropathy, and acute myocardial infarction.
Mechanism of action
General information about the mechanism of action of ACE inhibitors
can be found here.
Lisinopril is a lysine derivative of enalaprilat, the active
metabolite of the ACE inhibitor enalapril. In contrast to most of the
ACE inhibitors captopril and similar to lisinopril is not a prodrug,
but an independently active substance.
Lisinopril is used in combination with thrombolytics, aspirin and / or
beta-blockers for the treatment of acute myocardial infarction in
stable blood pressure, but can be used independently of ventricular
function. In studies, a significant increase in survival was observed.
Here, the negative consequence of myocardial infarction in the role of
angiotensin II is reduced, which is mainly in an increased oxygen
demand of the heart muscle, and thus expresses an increased necrosis
of myocytes. Especially when lisinopril is given together with
nitrates, the formation of a left ventricular dysfunction or heart
failure can be prevented or reduced.
At the recommended daily dose remains the antihypertensive effect is
maintained even during long-term therapy. I.d.R. it came into clinical
trials may not be clinically relevant changes in renal plasma flow and
glomerular filtration rate.
In hypertensive patients with type II diabetes mellitus and incipient
nephropathy (microalbuminuria) is in lisinopril not only reduced blood
pressure but also the excretion of albumin in reduced urine by about
40% (reference to an additional direct effect on the kidney tissue).
Lisinopril treatment does not affect the control of blood glucose levels.
Contraindications (contraindications)
The following are absolute Gegenanzeiegn (situations in which the drug
should be administered in any case) and relative contraindications
(situations in which the drug should be administered with caution)
listed. For more information or answers to your questions please use
the forum or ask your doctor or pharmacist.
Absolute contraindications
- Hypersensitivity to lisinopril or another ACE inhibitor
- A history of angioedema related to previous therapy with ACE inhibitors
- Hereditary or idiopathic angioedema
- State shortly after kidney transplantation
- 2 or 3 Trimester of pregnancy
- Age <18 years
Indication of acute myocardial infarction, in addition:
- Cardiogenic shock
- Systolic blood pressure <= 100 mm Hg at baseline
- Symptoms of renal impairment (serum creatinine> 177 micromol / l and
proteinuria or greater than 500 mg/24 h)
Relative contraindications
- Impaired immune response or Gefäßkollagenosen
- Volume and / or electrolyte deficiency (balancing possible prior to treatment)
- Impaired renal function (creatinine clearance <80 ml / min)
- Severe or renovascular hypertension
- Severe heart failure
- Bilateral renal artery stenosis or renal artery stenosis in a solitary kidney
- Hemodynamically significant aortic or mitral valve stenosis or
hypertrophic cardiomyopathy
- Pre-existing higher risk of symptomatic hypotension
- Ischemic heart disease (myocardial infarction at increased risk of
excessive blood pressure drop)
- Cerebrovascular disease (increased risk of cerebrovascular events
caused by excessive blood pressure drop)
- Breast-feeding
- 1 Trimester of pregnancy (if possible rapid discontinuation of lisinopril)
Side effects (adverse reactions)
This is a complete list of the known side effects, for more
information or answers to your questions please use the forum or ask
your doctor or pharmacist.
Adverse effects, without specifying the frequency
- Skin changes with fever, myalgia, arthralgia, arthritis, vasculitis,
eosinophilia, leukocytosis, elevated ESR and / or increased ANA
titers, photosensitivity
- Depression
- Syncope, arrhythmias
- Constipation

lisinopril and hydrochlorothiazide

Medical information on lisinopril and hydrochlorothiazide for high blood pressure.